Synthesis API — biologics CDMO proposals
Local model engineering
Reaching frontier-model quality with a local model
A self-hosted OLMo-3.1-32B model reached 7:6 parity against Claude Opus 4.8 on biosimilar CMC proposal generation — confirmed by a robust multi-judge panel, with zero fine-tuning.
Through retrieval engineering, deterministic validation, and prompt/enrichment techniques, we matched a frontier cloud model with full on-prem data privacy and a fixed monthly cost.
The quality gap was mostly elaboration depth, not knowledge — the most fixable kind. RAG and a few cheap, training-free levers reversed a 3:10 deficit into a 7:6 lead.